applied Neural PLasticity & dynamics
The brain has the amazing ability to change and rewire itself.
Lets use that as a tool and basis for treatment.
My CV (Curriculum Vitae)
Terry Kremin, PhD
Ernest Gallo Clinic and Research Center
University of California, San Francisco
5858 Horton St. Suite 200
Emeryville, CA 94608
The biological basis of reinforcement in learning and memory. How do we acquire behaviors, and choose between behaviors? What causes failures in the ability to adapt our behaviors to fit new situations and contingencies as in addiction and addiction-like disorders, as well as normal aging? My current research explores this issues using in vivo electrophysiology to record both individual single units as well as rhythmic activity and coordination in the hippocampus and nucleus accumbens.
Boston University, Boston, Massachusetts
D. Phil, completed December, 2003, awarded May, 2004
M.A. – Psychology, awarded September 2003.
Department of Psychology: Brain, Behavior, and Cognition Program.
Thesis Title: Cholinergic and GABAergic modulation of glutamatergic synaptic transmission in the hippocampus.
University of California, Los Angeles; Los Angeles, California
B.S. – Psychobiology
Departmental Honors. Honor thesis title: Win, place, or just show: The effect of reinforcer devaluation on a hippocampal-dependent task.
Dr. Patricia Janak, Ernest Gallo Clinic and Research Center, University of California, San Francisco.
In vivo electrophysiology in rats and effects of drugs of abuse. Performed in vivo recording simultaneously from hippocampus and nucleus accumbens, examining synchrony of individual units and field potential activity. Emphasis on temporal and spatial firing and synchrony at both the individual cell level as well as field potential levels, with particular attention to changes in theta and gamma rhythmic activity. Developed new operant behavior paradigm dependent on the hippocampal formation.
Graduate student, Teaching Fellow, & Research Fellow
Dr. Michael Hasselmo, Department of Psychology, Boston University, Boston, MA.
In vitro electrophysiology of hippocampal and piriform cortex synaptic transmission. Extracellular recording of cholinergic inhibition of transmission and layer and mAChR subtype specific effects in rats and M1 mAChR knock out mice as well GABA time course effects in the hippocampus of rats.
Graduate student & Teaching Fellow
Dr. Katherine Kantak, Department of Psychology, Boston University, Boston, MA.
In vivo research on behavioral systems utilizing lidocaine temporary inactivation techniques and cocaine addiction and reinstatement in rats utilizing self-administration paradigm.
Undergraduate honors research project with Dr. Barbara Knowlton, UCLA, Los Angeles, CA.
In vivo research using reinforcer devaluations (conditioned taste aversions) in hippocampal and caudate nucleus dependent tasks.
Lecturer at University of Massachusetts, Boston; Boston, MA
Courses: Psych 255: Sensation and Perception, Psych 250: Learning and Memory
Teaching Fellow, Boston University, Boston, MA
PSY234 Learning, under Henry Marcucella; PSY322 Experimental Psychology: Physiological Laboratory under Jim Cherry; PSY101 Introduction to Psychology under Richard Ely.
Kremin T, Hasselmo ME. Cholinergic suppression of glutamatergic synaptic transmission in hippocampal region CA3 exhibits laminar selectivity: Implication for hippocampal network dynamics. Neuroscience, in press.
Kremin T, Gerber D, Giacomo, LM, Huang SY, Tonegawa S, Hasselmo ME. Muscarinic suppression in stratum radiatum of CA1 is dependent on both M1 and M2 receptors and is not dependent on GABAergic interneurons. Neurobiology of Learning and Memory, (2006), 85(2):153-163
Kantak KM, Green-Jordan K, Valencia E, Kremin T, Eichenbaum HB. Cognitive task performance after lidocaine-induced inactivation of different sites within the basolateral amygdala and dorsal striatum. Behavioral Neuroscience (2001), 115(3):589-601.
Kremin, T & Janak, PH. Simultaneous, bilateral nucleus accumbens and ventral hippocampus recordings in rats during an operant conditioning task demonstrate coordinated activity. Society for Neurosciences Annual Meeting, Atlanta, October, 2006.
Kremin, T. Differences in referencing techniques produces qualitative changes in in vivo electrophysiological recording: Examples from a single animal. Invited talk, Plexon User’s Group, Society for Neurosciences Annual Meeting, Atlanta, October, 2006
Kremin, T. Cholinergic and GABAergic modulation of glutamatergic synaptic transmission in the hippocampus. Doctoral dissertation, Boston University, Boston.
Kremin T, & Hasselmo, ME. Cholinergic suppression of synaptic transmission in region CA3 of the rat hippocampal formation shows laminar selectivity. In final edit for submission.
Kremin T & Hasselmo ME. Cholinergic suppression of synaptic transmission in region CA3 of the rat hippocampal formation shows laminar selectivity. Society for Neurosciences Annual Meeting, New Orleans, November, 2003.
Kremin T, Gerber D, Huang SY, Tonegawa S, Hasselmo ME. Muscarinic suppression in stratum radiatum of CA1 is dependent on both M1 and M2 receptors and is not dependent on GABAergic interneurons. Society for Neurosciences Annual Meeting, Orlando, November, 2002.
Kremin T, Gerber D, Huang SY, Tonegawa S, Hasselmo ME. Muscarinic inhibition of hippocampal EPSPs is attenuated in mice lacking M1 subtype acetylcholine receptors. Society for Neurosciences Annual Meeting, San Diego, November, 2001.
Kremin T, Eichenbaum HB, Kantak K. Effects of reversible basolateral amygdala inactivations on a caudate nucleus-dependent task. Society for Neurosciences Annual Meeting, New Orleans, November, 2000.
Kantak KM, Valencia E, Black Y, Kremin T, Green-Jordan K, and Eichenbaum HB. Basolateral amygdala cognitive function and cocaine-seeking behavior. College on Problems of Drug Dependence (CPDD) Annual Meeting. San Juan, June 2000.
Green-Jordan K, Valencia E, Kremin T, Eichenbaum HB, Kantak K. Cognitive task performance following bilateral lidocaine lesions of different sites within the basolateral amygdala and dorsal striatum. Society for Neurosciences Annual Meeting, Miami Beach, November, 1999.
Kremin T, and Knowlton BJ. The effect of reinforcer devaluation on performance in a hippocampal-dependent task Undergraduate Research Conference, Los Angeles, California, 1998 and UCLA Brain Sciences, Los Angeles, CA 1998
In my office at Boston University. In full winter trim!
(my Academic resume)